Mrs. D., I wanted you to know that my father is showing some positive changes in his mental functioning- we started with B-12 and B-1. Hopefully this isn't a placebo effect, and the Bs are working for him. No input/suggestions from his doctor, we just feel stonewalled, and since we can't get any guidance from him, we don't feel it is possible to start EFA's, do you agree? Also, I want to consider SAMe for him, but wondered about interactions with his other drugs. I can't find any reactions specific to the drugs he is on, but don't want to miss anything, either. If you have time, your input would be appreciated. Thanks so much. Julie