I agree Fiona..There are so many variables, and conditions that contribute to the overall status of our physical and mental health..I know for a fact that fear, anxiety, worry and depression will put me down, and peace, serenity, laughter, and happiness picks me up physically..When I am struggling I have to take a look at the condition of my emotional status, and Ive found that when my mental health is bad, pd meds wont rescue me from its wrath