Both hands and feet? This can be carpal tunnel (hands) and tarsal tunnel (the feet).

Lupus can affect the joints. If this happens, then the ligaments around the wrists and ankles can be compressed and then the nerves going thru them act up.

I had both carpal and tarsal tunnel with my undiagnosed hypothyroid.

Another thing in the feet it could be (but this would not affect the hands), are cracked or displaced sesamoid bones. An Xray at the foot doctor's will show this.

You can buy the wrist braces for carpal tunnel and wear them at night to see if your hands are better after doing this during the day. The braces keep your hand in a position that relieves pressure on the nerves in the wrist. If not, then perhaps some testing of the neck area for pinching nerves there.

I don't know of any vitamin which would have 800mg of B12 in it. Many mixtures might have 800mcg of folate however. But more commonly they have 400mcg. B12 would be stated on the label in mcg= micrograms as well as the Folic acid. The other B's would be in mg or milligrams.
Can you post your brand on this thread so I can look it up?

People with systemic Lupus can have many various places where the body attacks itself. So one cannot disregard that potential.

BTW Lotrel contains Norvasc as one of the two drugs. This drug causes significant dependent edema in some people. It could be causing swelling in your feet /or legs eventually.
This is a fairly well known effect...it happened to me years ago when my doctor tried it for me. It was so bad for me I could not bend my knees...I stand on my feet all day in my job. I didn't last a month on it.
http://www.netwellness.org/question.cfm/51583.htm
This article claims up to 10% may get peripheral edema:
http://www.rxmed.com/b.main/b2.pharm...)/NORVASC.html