When I was diagnosed my Vitamin D level was at 17. This was 18 months ago. I have managed to get it up to 46 now after doing the 50,000 a week for awhile, taking a break for several months, and then starting on daily supplements. The neurologist who runs my clinic likes to see all MS patients in the 60s-80s range. I have been taking 3,000 a day and may bump up to 4,000 a day. I would like to get it higher!