Hi short out line: given Zantac for so called Refluz put up to 4 x 300mg per day and left on it for 5 years, problems reported, all over joint problems, muscal fatigue, and memory problems, at last a change well to Zoton 1 x 30mg PD for 6 more years, no change, private blood test showed 7 food intolerances plus a IgE antibody problem, so did I have Refluz for the past 11 years or just a food intolerances, what I do have is no life, joint problems, muscal fatigue run my life now my heart muscles are starting to give problems, may be if you are on Zantac or Zoton for Refluz ask try cutting out foods 1 by 1, more and up to date details if needed.