This is the absolute first time I've heard of single ketamine injections.

I have heard of the short ketamine treatment (infusion for a few hours, dayclinic) and the long ketamine treatment or coma treatment (done in Germany).

Maybe you could contact RSDhope or the RSDS national support group and try and find out what this treatment is all about. They know a lot about ketamine treatment.

It's odd, I think, this treatment... never heard of it. If the above groups haven't heard of it, I'd bring this up with the doctor.

Your wife should go with her gut feeling!