Adrenal fatigue, according to MSM, doesn't exist, is all in your head, and only girls get it and you know what that means...

PubMed seems to have missed the memo and turns up 900 hits. This one really makes me pause-


1: Med Hypotheses. 2009 Jun;72(6):701-5. Epub 2009 Feb 23.

Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome
reflect a 'crash' in the stress system?

Van Houdenhove B, Eede FV, Luyten P.

Department of Liaison Psychiatry, University Hospitals K.U. Leuven, Herestraat
49, B-3000 Leuven, Belgium.

The etiopathogenesis of chronic fatigue syndrome (CFS) remains poorly understood.
Although neuroendocrine disturbances - and hypothalamic-pituitary-adrenal (HPA)
axis hypofunction in particular - have been found in a large proportion of CFS
patients, it is not clear whether these disturbances are cause or consequence of
the illness. After a review of the available evidence we hypothesize that that
HPA axis hypofunction in CFS, conceptualized within a system-biological
perspective, primarily reflects a fundamental and persistent dysregulation of the
neurobiological stress system. As a result, a disturbed balance between
glucocorticoid and inflammatory signaling pathways may give rise to a
pathological cytokine-induced sickness response that may be the final common
pathway underlying central CFS symptoms, i.e. effort/stress intolerance and pain
hypersensitivity. This comprehensive hypothesis on HPA axis hypofunction in CFS
may stimulate diagnostic refinement of the illness, inform treatment approaches
and suggest directions for future research, particularly focusing on the
neuroendocrine-immune interface and possible links between CFS, early and recent
life stress, and depression.


PMID: 19237251 [PubMed - in process]