Hi, I was recently surprised by an article on my site about Dr. Chandy who practices in England. I'd forgotten that it said some of his patients with Multiple Sclerosis responded well to B12 replacement therapy...

When I read your description of how jeans no longer felt comfy, it reminded me that when I was very low on B12 I could barely stand the seam in my silky slip against my body...

And yes, I didn't have to have on my slip with its seam in order to feel the discomfort.

My "discomfort" felt like a third degree sunburn a lot of the time, but sometimes it was a more complicated discomfort.

B12 can play a part in how we feel when we have serious health problems aside from low B12. For instance, I had tetanus and couldn't get a doctor to see me because I didn't have enough money... later my home was foreclosed and I got to see the Homeless Doctor (not him, his patients) and then I was finally able to get the Metronidazol to kill the bacteria.

Which I mention because when I didn't have anything else to take I used a lot of extra B12 shots... and after a number of weeks my peripheral neuropathy began to go away, and then it went almost entirely away. I wasn't expecting that. I was just hoping I could keep breathing all night long, night after night.

What I mean is, B12 didn't cure my tetanus but it did improve how I felt...

Take a look at a list of symptoms of low B12, and if you are dealing with several of them, get some methylcobalamin lozenges and try them for a couple months, I'd say the 5mg lozenges, and keep notes so that you can look back and see if there were changes which you might have forgotten once the improvements grew familiar.
.