SAMe was mentioned at the pain conference I attended two Springs ago. It was classed as a "mildly effective" thing to try.

We have a SAMe thread going on Vitamin forum right now. I think you could benefit from reading it.

SAMe raises synthesis of neurotransmitters in the brain. One of those is serotonin, which is the major one, along with norepi, a minor one, that are both useful for reducing the pain loop in the brain that Fibro is caught up in. There is a complex pain loop that I can't begin to explain here... they showed it to us, at the seminar. It is way beyond me and others here.
But suffice it to say, it does exist!

I have a thread here from that seminar:
http://neurotalk.psychcentral.com/sh...highlight=mrsd

I am going to see if I can get this stickied...so I don't have to keep searching for it. At the end of May this spring is another conference...which I plan to attend. They will be having another Fibro portion. (This is connected to the University of Michigan and a tertiary specialty pain group that works there).

Sorry to be late to this thread.