Mrs. Doubtfyre, how long would it take before you would notice a change in yourself after you start taking SAMe? I started with 400 mg. yesterday, and can swear I feel better- is it just wishful thinking? I know I should have started with 200 mg., but picked up the wrong dosage, will that matter too much? I hear you about wanting to get outside to garden . . . we just moved to Colorado (Denver area) and everyone says to wait until after Mothers' Day to move anything outside. My mental health is faltering, I need to go play in the soil!