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Old 04-19-2009, 07:50 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
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mrsD mrsD is offline
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mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
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This quote is for D2 (ergocalciferol) which is used on RX only in
50,000 IUs.

Quote:
The in vivo synthesis of the major biologically active metabolites of vitamin D occurs in two steps. The first hydroxylation of ergocalciferol takes place in the liver (to 25-hydroxyvitamin D) and the second in the kidneys (to 1,25-dihydroxyvitamin D). Vitamin D metabolites promote the active absorption of calcium and phosphorous by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules.

There is a time lag of 10 to 24 hours between the administration of vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. Parathyroid hormone is responsible for the regulation of this metabolism in the kidneys.
from http://www.rxlist.com/calciferol-drug.htm

The 50,000 IU is designed to last about a week.
When you take the D3, you will not have the "lag" time to get the active hormone. You will also not be taking so much at one time. There might be something in the gelcap that you are reacting too as well.

I see in your profile you take oxy? This can cause itching, too.
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Last edited by mrsD; 04-19-2009 at 09:26 AM.
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