I was put on a tricyclic anti-depressant many years ago, just to see if it would help with the pain. Tricyclic anti-depressants are commonly prescribed in RSD, they are older generation anti-depressants but work better for RSD (read that somewhere, don't ask me where). For me, the anti-depressants didn't do a thing, except help me sleep better. For that reason alone, I wasn't allowed to take them, because of the many possible side-effects. The newer ones were tried also (SSRIs) and I had an adverse reaction to them. So the anti-depressants were out the window quite fast.