I am sorry to hear about your news. After my experiences with all of the CRAB's I have no words of advice to offer regarding drug choice. At times, it would almost be a relief to just be told this is what you must do.

Tysabri is a big deal, but alot of people seem to be experiencing success with it. Betaseron is typically the CRAB treatment prescribed for those that are classified as SPMS as well as others. There are a few other options out there such as rituxan or chemo, but I have not been willing to try them as this point.