PubMed Article
Mov Disord. 2009 Apr 7
Immunopathogenic mechanisms in tourette syndrome: A critical review.
Martino D, Dale RC, Gilbert DL, Giovannoni G, Leckman JF.
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Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability
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Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics.
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