OP1 is BMP7 and is very expensive, I believe 5,000 dollars a bottle. My wife went through a 3year non union of the tibia resulting in 27 operations and 4 external fixators. The OP1 was brand new at the time ( 2003). It did not work for her either. She eventually fused only after having a taylor spatial frame put on, which is an external fixator that is tightened everyday at home. She also started taking calcium and of course having to bear weight on it. If bone isnt stressed it doesnt heal completely.