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My doctor once tried to prescribe Tramadol and Effexor together, and the pharmacy caught the interaction and did not fill the prescription for the Tramadol (Ultram).

Then I stopped the Effexor, and the doctor had put me on Flexeril (muscle relaxer) and the doctor tried to prescribe Tramadol/Ultram again - and again the pharmacy caught an interaction between Tramadol and Flexeril.

So, after that, my doctor stopped prescribing Ultram/Tramadol for any of her patients due to the number of drug interactions it has.

It's a good thing that you paid attention to the potential interactions, because as mrsd said, most doctors have no idea about drug interactions... Thankfully, most pharmacists use computer systems, so even if they forget an interaction the computer will remind them -- one more reason why patients should always use one pharmacy for all of their prescriptions!

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Liz