From what I have read in the past, it is considered Total IgA deficency if you have a total IgA of 7 or below. I've seen slight variances in this value, like 10 instead of 7. However, even if you are just below normal range in total IgA, you can still be considered IgA deficient.... just not completely IgA deficient.
The degree to which "low" IgA affects IgA antibody testing is debatable, however, there has been at least one celiac expert who has said "it can" make a difference. If you make less IgA overall, it makes sense you may make less antigliadin IgA. It may not be a factor in your case.
What antigliadin IgG means is not well defined. It is the least specific of the markers for indicating villous atrophy, and it is seen in conditions other than celiac disease. I have heard it explained that antigliadin IgA is more specific for villous atrophy, and antigliadin IgG may be seen more often in non-gut manifestations. Still, I have met several biopsy proven celiacs who had only an isolate antigliadin IgG.
Statistics for what these various tests mean vary depending upon the study, but here is an example of how specific they are to celiac disease defined by villous atrophy.
Dr. Hadjivasiliou's research with gluten sensitive neurological disease says that antigliadin IgG is the most specific marker available in these patients.
Leaky gut syndrome is making "mainstream" medicine, however, you will more likely see it referred to as intestinal permeability rather than leaky gut syndrome. Probiotics are beginning to make "mainstream" medicine, too.
There is something called zonulin, a protein which controls the tight junction spaces in the intestinal lining and the blood/brain barrier. Dr. Alescio Fasano, a leading celiac researcher, discovered this less than ten years ago. People with celiac disease, diabetes, MS, and other autoimmune diseases have been found to produce more zonulin than the average joe. A zonulin blocking drug is currently in clinical trials that may be used to treat celiac disease, diabetes, and possibly other autoimmune disease.
http://jccglutenfree.googlepages.com/zonulin
And, other things can cause leaky gut, too, like bacterial overgrowth, yeast overgrowth, parasites, viruses, etc. And this may lead to gluten and other food sensitivities, without celiac disease.
This is such a huge subject, and currently under heavy research. They know more today than yesterday, and will know more tomorrow than today. In the meantime, a gluten free diet would likely help you~ btw, there is a page on psoriasis and gluten in the The Gluten File, too. The most recent study, 2009, is this:
Quote:
Nutritional influences in psoriasis
Araujo ML, Burgos MG, Moura IS.
Universidade Federal de Pernambuco, Recife, PE, Brazil.
Psoriasis is an inherited inflammatory skin disease mediated by T-cells and influenced by environmental factors. High intake of omega-3, fasting, low-calorie and vegetarian diets show beneficial effects. Some patients presenting IgA/IgG antigliadin antibodies and who are gluten-sensitive improve after a gluten-free diet. Calcitriol is used in topical treatment. The use of alcohol may exacerbate the disease. In this report, diet factors are analyzed and their benefits in psoriasis are described.
PMID: 19377768
|
Just keep reading and talking to others who have gluten sensitivity. Do keep taking the B12 forever, too! I had some of those same symptoms when B12 deficient. I hope you will decide to do a six month gluten free trial, at least, to see if you notice any differences. Many who have problems with gluten also have problems with casein (cow's milk).
The energy part... I still struggle with this... and it always amazes me that when I get back on a full regimen of vitamins... I am always more energetic. Most recently, I have found supplementing vitamin D this winter has helped my energy level. I also need to be sure to take a B-complex, and supplementing omega 3's can help with energy levels, too.
Do you have thyroid disease?