My DH used to take Zyrtec at bedtime, but his Dr switched him to Xyzal and he's doing well on it. His Dr switched him b/c the Zyrtec went OTC and the other is an RX that ins pays for. I keep Hydroxyz HCL (RX) on hand for when I need it and sleep like a rock when I do take it. (usually just during allergy season or if my skin condition flares.)