Quote:
Originally Posted by aquario
Found the following abstract online:
By adding creatine to the diet of parkinson's induced rats, the researchers saw significant reduction in involuntary movement without any worsening of pd symptoms.
Jon
(caveat: hopefully it doesn't matter that one of the researcher's names was G. Quack . . .  |
I looked up Wikipedia on the use of Creatine and scared myself reading about side effects, in particular genesis of "compartment syndrome". Check with Wikipedia using the keyword "Creatine" before you launch in to its supplementation.
Just a short quote:
"Side effects that produce lower leg pain may be associated with the use of creatine. Creatine may be the cause of an increase in the anterior pressures of the lower leg. This is usually found in post-creatine use when at rest and after exercise. Normal at-rest pressures have been found to be highly elevated by subjects who used creatine within the prior 35 days when compared to no supplementation. This can produce an extreme amount of pain in the lower leg due to the rigidity of the anterior compartment of the lower leg and lack of fluid drainage out of the compartment. It may also be exacerbated by the increase of water content in the muscle fibers, putting more pressure on the anterior compartment. If this condition persists, check with your doctor and inform them of your creatine use and dosage. Although this condition may and usually does subside, if left untreated complications may occur that require emergency medical attention. If the levels remain high for a long period of time, irreversible damage to tissue may occur, particularly to the peroneal nerve. These conditions can further be found under Chronic Compartment Syndrome.[13]
A single case report in 2008 with a young patient with acute cholestatic liver injury who was supplementing with creatine and whey. However, the cause was inconclusive. The patient did recover after administering intravenous fluids and discontinuing supplementation. Cause was most likely severe dehydration due to overexertion."
Kenki