I do leave it be but after 30 years of marriage and knowing her and her family just as long and the fact that her mother is in her 80s it does bothers me and will bother her if something drastic happens to her family members. She always had a close relationship with her family up until she developed RSD. I don't put undo amount of stress on her but the family thing never-the-less bothers me because I feel its not good. She once told me if her father was still alive none of this alienation business would exist, in that he would have rallied the family around my wife instead they stay away. Its quite sad.