I know many people who have found good relief with Imipramine and the other lower dose older antidepressants. My doctor prescribed Imipramine for me over a year ago for another pain condition, but unfortunately, it caused me to have excessive tachycardia and pvcs. I did however, already suffer from these problems previously, but apparently the drug really made it worse. Keep in mind though that we are all different and like any other drug, not everyone suffers the same side effects. Good luck.