I agree with those who said that here is little or no correlation between lesion load and disability.

I have never known how many lesions I've had, but I do know that I am SPMS, and have had no exacerbations since my last MRI, in 2000/2001?

I may have one or two or a million lesions added, in the last 6 yrs, on LDN, but I have had almost nil progression of MS disability.....unless you count the disability of aging..

I have said and I still say, that, if you have been DXed with MS and you don't suspect anything else, or are in a Trial, an MRI is redundant, useless, unnecessary and expensive..