betaseron.com has a nice program where another person who matches your lifestyle will call and talk to you about their experience. peer mentoring. its kinda cool.

I have a friend who has been on it 8 years now, and went from being horribly ill to quite stable. She has the occasional fever after the shot, but takes an advil, and goes to bed.

Most folks take it at night to avoid the side effects. I did, and that worked great.

Check out the NMSS.org Betaseron.com or google it.