I tried Neurontin and it was really bad for me. I take Lyrica now at 150mg. night and morning. Recently the doctor tried increasing my Lyrica but it made me extremely nauseated, but backing down to a lower dose got rid of that. I also take Trileptal in the morning and at night and at bedtime I take Flexaryl. I almost think the Trileptal does better for me than the Lyrica, really. If I forget the Trileptal for even two or three hours, my burning starts back up again. Oh, I also take 5mg. of prednisone a day, but that's because my PN seems to be a genetic inflammatory condition. I don't have any weight gain with the Lyrica and no swelling. With Neurontin, my legs swelled horribly.