ALA in conjuction with B12 is used by German MDs to treat PN resulting from diabetese, they have not shown it to be effective Idiopathic PN as of yet. Two major clinical tests are going on in separate medical schools, in in Moscow Russia and one in the US to test the German's claim. ALA helps the neurosystem and brain absorb vitamins Bs, C, D and E or so I understand, this is the route I am taking. Seems to help, I have had this PN for 2-3 decades, but only in thelast 5 years has surge significantly. It now covers 100% of me. I also used physical therapy tok retrain my body to rely on occula and vestibular mechanisms of balance. However, either the suppliment are helping or they are the best plecebos in existance. My intern say definitely take the suppliments. This conditions has gotten highly aggressive, so I am getting much more aggressive in my supplimental treatments. Regarding your feet, both my feet have no feeling with respect to pressure and my hands are almost as bad. Two of my MDs prescribed 10 - 18 inch boots, firm but not hard leather with high arches, as a result of these boots I can walk with out support and it feels like I can feel the ground again. Also, I have really severe stenosis up most my spine and am facing several more surgeries. After the first laminectomies of L4, L5, S1, S2 I got tremendous relief from the PN, it has since returned. We often think MRIs etc show all the points of compression that might cause PN, but that is not the case, as I learned I might just have a really tight spinal canal, as cortisone epidurals really help. So I am using everything I can find. CoQ10 looks promising, but I cannot tolerate it, mkes me sick.