I know all meds don't work for everyone. it sounds like this person had 3 good years. I know that now drs. are RX Opana ER. Opana has only been on the market for about 3 years now, so she must have gotten in on the ground floor. She needs to discuss this with her dr. and find out if he can increase her dose. I have discovered thru research that if you are taking Opana ER, and you need breakthru meds, that you should have Opana for it. THey don't recommend mixing Opana with other breaththru type. I don't know if that has anything to do with it. Her dr. would know better then I as I am not a dr. All I know is that I have my life back, I can get on the floor with my cats and dogs and play, I sleep about 10 hrs a nite, I've planted a veggie garden. And to think that a couple of years ago, I was in bed or a wheelchair. I can now go grocery shopping and walk with a cart, and can carry in some of the lighter bags. It doesn't sound like much, but for me it's wonderful.

Mary