I'm also a rule-keeper, by the book type of person, and for the first two and a half years, I think I only missed one shot (Copaxone) and that was not deliberate.

The last few months, I've had a bad day here and there, and just said, "nah, not tonight."

I've never read anything (or don't remember) that indicated a change in efficacy if a shot were skipped once a month, once a week, whatever.

There's no way they can really "prove" anything about this stupid disease anyway. If I get worse, does that mean the Copaxone isn't helping? Or does it mean that if I weren't on the Copaxone, I would have gotten a LOT worse?

If I skip one shot a week, does that mean I'll end up in a wheelchair two months sooner? Does it mean I've interrupted the system and it won't work at all? Does it just mean I have less in my body so it works less efficiently?

This isn't a good day for me to be answering this question, I guess.