I have to admit that sometimes I wonder if it makes a darn if I skip one now and again. The success rate is so low for this stuff anyway, and I get miserable with lumps, and so on. The MD said a mental health day break can be more beneficial than being on this every single day no matter what. Sometimes it beneficial to be naughty for a day. I could have hugged him. Till then I had not missed a single shot unless told to by the MD, and was ansty about it. After 2 years of being on this, I am not so panic stricken anymore if I miss one once a month or so. I do make it a massage day if I miss.