I have used Rebif and I have used LDN.

Rebif - no side effects. It has an auto injector so even though I HATE shots, it was no big deal. I called a diabetic friend of mine, she recommended the stomach as it has the most fat. Of all the injection places, it was the best for me. It just took a bit of mental bravery to stick my soft belly!

It was just a hassle to inject at about the same time in the evening. There is a support system, the pharma WANTS your business.

why Rebif? The thought was that you get more medicine in smaller doses so there are less side effects. True? I really cannot answer that.

Effective? I don't know. I was dx'ed PPMS after a year so DMD's do not apply.

LDN - My MS doc had no problem. It is in such a low dose form, it cannot harm and if it does good, well all the more power to it. I would talk to him again.

For me, it had a negative effect but it appears it is only me. I lost my balance a lot. So much that I broke my shoulder. Since LDN was the only change I had made in medication, it just seemed smart to eliminate it. My balance is back to "normal."

So there are my thoughts. Sorry things are so stressful. Get a mint julip and sit on the porch!