Hi Karen Marie, After My Nap and All,
Here's my two cents worth to be added to the group.

I noticed a difference with my symptoms with LDN as soon as I started to up my dosage to 3.0 mg. I took 1.5 mg for 10 days, and felt pretty good. Then started taking 3.0 (two capsules at night). It seemed to help more and more after two weeks of being on the higher dosage.

I felt real good. I never had a down day since. Even with the 1.5 mg dosage. MS can surely give us some down days, but I was always in a great mood, even with the Christmas hassles and all past holidays. Also with the stress of my kids, and family too

I am still feeling great. Increased endorphins, or making more now, when I might not have been making enough could be the answer to feeling good, IMO. I may have been low, I don't know.

I don't want to ever stop taking LDN to find out. Laughter and happiness is wonderful. I never really laughed out loud so much before. I am happy.

Then small symptoms got better. Then bigger things like balance and walking got much better, without me even realizing it. My DH noticed the changes more than I did. My Neuro finally saw them too while testing me for my regular exam. It is now in her records.

I find I can look back easier to notice the improvements, than picking them out day by day. The benefits are so gradual and smooth it surprises you when you can do something that you haven't done in years, and not even realized you are doing it. It's still amazes me!

My PCP gives me the script and I get it at Skip's in Florida, by mail. I get a 90 day supply. I have 5 refills on it too. I have been very happy with the results, and all the better health benefits I have received by taking LDN.

I don't feel I need to increase it at this time to the 4.5 dosage. We are all different with our symptoms. We all metabolize the drug differently. Some need more than others, just like a pain medication. I am only on it since December 2008.

But, I must repeat myself. The five months on LDN has changed my life, my outlook, my energy, my worst symptoms, and my other auto-immune diseases have been helped too. I have tried the DMD's (CRAB's) for years with very little help from them, and many bad side effects while on them for me.

The DMD's could not do what LDN has been able to do for me. The other MS meds like Neurontin and Provigil, etc., I have been able to wean off of them too. If I find need steroids in the future, I would just add them.

So I would like to say, good luck to both of you, all of you. Just give it time to work for you. Also think positive thoughts too. I pray you both see great improvements. It can't hurt to try LDN. We try old and new drugs all the time with this disease.

I must admit, it hasn't helped the MS hug. During the day it is better but at night it is noticeably there. My choking is gone, for good I pray. B & B issues have gone too. See, if I think of them, I noticed things have gotten much better.

Be well everyone, no matter what drug you are depending on for help.