Quote:
Originally Posted by fmichael
My pharmacist reads to me from his text, that QT issues involving Methadone are "generally associated with higher doses," which in turn are defined as "> 200 mg/day."
Vel non Torsades de Points, I wouldn't want to know how 200 mg./day of Methadone even felt!
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Please give your pharmacist the University of Arizona website.
Combination factors will potentially affect response to methadone.
200mg is really a high dose. Very few people get to that place.
Here is another link:
http://www.cdc.gov/nchs/products/pub.../poisoning.htm
Quote:
From 1999 to 2005, poisoning deaths increased 66 percent from 19,741 to 32,691 deaths, whereas the number of poisoning deaths mentioning methadone increased 468 percent to 4,462 (Figure 1). Poisoning deaths mentioning methadone increased from 4 percent of all poisoning deaths to 14 percent of all poisoning deaths. Most recently, all poisoning deaths increased 8 percent from 2004 to 2005, whereas those mentioning methadone increased 16 percent.
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This reflects the increased use of methadone to treat chronic pain.
I don't have figures past 2005 at this time.
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