This is really interesting. I'm taking one 25/100 Sinemet 3x a day along with 0.75 mg. of Mirapex. I'm still working, and it's been hard lately being stiff and slow from about 11:00 to 1:00 when I'm waiting for the next dose. I see my neuro the end of Jan. and I'll ask him about Zelapar - I'd rather not take any more Sinemet if I don't have to. Is it a brand new drug?