Thread: Imipramine
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Old 05-27-2009, 07:49 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
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While Tegretol has been used for nerve pain for a LONG time, successfully, it has significant drug interaction risks.

Here is a link to 3 moderately severe ones:
http://www.drugdigest.org/wps/portal/!ut/p/c0/04_SB8K8xLLM9MSSzPy8xBz9CP0os3gXDzcPZz8fI0MLLzNjAy NzMzcfCx8zQ5MQE_1wkA6zeAMcwNFA388jPzdVP1I_yhy3Ocb6 YXn5Rbkg-8oyU8v1Q0CmJiaD3KAfmZyRmpztmVeSWgQRKQZJFpekFuhHZua lpFYAzY7Ea3ZBdl55eUhqkm6goiIAN2XQGw!!/dl2/d1/L0lJZ2ttR0EhL3dQRUJKRXBxQU1vQS9ZSTU0NTAtNUZ3ISEvN1 9ESEZIQ05MMjE4SjYzMDI3NkZMOEw2MTRUMy86b19fXzIz/?drugList=340&cD=101&cD=340&dN=Tegretol+Tablets^To franil+Tablets^&step=check&CheckFDA=1#7_DHFHCNL218 J630276FL8L614T3

I would print them out and take to the doctor for evaluation for you. It might be that the Tegretol is all you need at this time and the Imipramine could be dropped entirely.

edit: oooopppssss for some reason the link to Express Scripts drug checker does not auto link here. You have to highlight the whole thing and copy/paste it into a new browser search window.

I just tried that and it worked. If you fail somehow doing this go to
this link
http://www.drugdigest.org/wps/portal/ddigest
click on check interactions
and put both drugs into the search box and hit enter.
3 interactions will appear.
this is a quote from the first one:
Quote:
CARBAMAZEPINE (in Tegretol Tablets) may interact with IMIPRAMINE (in Tofranil Tablets)

Carbamazepine and imipramine are both broken down and removed from the body by the liver. Carbamazepine may cause imipramine to be broken down at a faster rate than normal. If this happens, then potentially less imipramine would be available for the body to use and blood levels could become too low. This could make imipramine less effective. On the other hand, imipramine may block the breakdown of carbamazepine by the liver. If this happens, blood levels of carbamazepine could be increased and this could increase the risk of side effects. Side effects that may occur with the use of carbamazepine include drowsiness, dizziness, headaches, and blurred vision. More serious or potentially life-threatening side effects include repeated infections due to a decrease in white blood cells, excessive bleeding due to changes in the blood's ability to clot, a rare type of anemia that comes on suddenly and can be fatal if left untreated, damage to the liver, and a loss of effectiveness in some type of seizure disorders that normally affect children. If carbamazepine and imipramine are used together, your doctor may want to monitor you closely when therapy with either drug is started or stopped. If you are experiencing problems, it may be necessary to adjust the dose of either drug.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

This interaction is well-documented and is considered moderate in severity.
The others involve use with grapefruit juice and food interactions.
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