Sorry to take so long to answer you! My online life is suffering while the real one runs amok...

When I started Estriol in October 2007 (along with Copaxone) I was beginning to have major problems with balance. If I went shopping I had to have a cart. Walking was getting increasingly difficult, and I couldn't work in the kitchen for more than 5-10 minutes without stopping to rest. I really felt that I would not be walking for much longer.

A month later I requested an antidepressant. I don't know if the black cloud I was under came from the Copaxone, the Estriol, or just hating winter.

I noticed some increased sensation in my extremities pretty quickly - within two months. By late Spring my balance had improved enough to stand on one foot without falling over. I spent nine hours on my feet grocery shopping and cooking in preparation for Thanksgiving dinner 2008. I could not have conceived being upright that long....not since 2003! The improvements in my legs and feet have been dramatic, IMO.

The intention tremor that started in my left hand has worsened and migrated to affect both hands now. That sucks. But the balance and stamina are so much better... I wonder why only one worsens?? I gave up Copaxone in March due to inadequate medical insurance. In the three months without it I have not had any worsening of or new symptoms.

It takes an MSer to appreciate the ability to do things like step over the cat without having to hang on to something. I like it - I feel much more confident on my feet than I used to.

In short, it helps. Not completely, but a lot.