On this issue of Naldextrone for anxiety. The article here is not referring to the Low Dose Naldextrone that is actually said to boost the endorphin system in the brain. Instead it looks like they purposefully used the high dose of this med which is clearly designed to block these receptors. It does make sense than that the outcome of the study says it will Increase anxiety. Would be interesting to see a similar study of folks taking the low (4 mg) dose instead of the high (50mg dose).