In the past year - i have taken Diclofenac Sodium (voltaren XR?) - thats a NSAID - so you can only take painkillers w/ acetimenophen (sp?) with it. It worked alright. I've also been on several methlyprednisone/Medrol dose packs - thats a steroid, and it helped well for a week or 2. However, the problem is that it can lower your immune system - I had a cyst flare up that required surgical removal after i was on that.