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Old 05-31-2009, 07:43 AM
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reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default Sensorimotor gating

Joop-

I don't know if you were around when Anne Frobert and I were experimenting with the effects a simple cloth band around a leg or arm or even forehead on tremor and control. This led to the realization that there is another component to the action of a muscle group beyond simply "activate-release", namely sensory feedback informing the brain that the indicated action has taken place.

Perhaps there is a clue there. Maybe a process such as-
1) Signal muscle "A" to contract;
2) Receive confirmation that action is taking place;
3) Signal muscle "B" to relax;
4) Receive confirmation that action etc.

Blockage at step 2 would result in both muscles being contracted, thus freezing.

There is some interesting stuff at http://scienceweek.com/2004/sb040813-2.htm
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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