For Jim, it's been 21 years and so far no damage anywhere that we know of. He's been on A, B and C and once Novantrone. He's back on B because the A caused too many flu symptoms and C caused to many skin reactions. But we are thinking C again because B seems to cause more symptoms like muscle spasm and tightness after the shot. Who knows, but Jim would rather be on something than on nothing.
Good luck in whatever you try. I don't know if there is long term damage after 21 years but so far so good.