Pristiq is just a variant on Effexor. It is therapeutically the same IMO. Effexor has a very short half life, so they diddled the molecule to make it more potent.
The Savella has less SSRI actions I believe than Effexor. That is what you are probably feeling.
The conference I attended made a reference to the norepi system being stronger in some pain responses. So Savella is an option for that. But it can raise blood pressure. So far it does not have the liver warnings that Cymbalta has.
But it can alter liver functions some:
Quote:
In the placebo-controlled fibromyalgia trials, increases in the number of patients treated with Savella with mild elevations of ALT or AST (1-3 times the upper limit of normal, ULN) were observed. Increases in ALT were more frequently observed in the patients treated with Savella 100 mg/day (6%) and Savella 200 mg/day (7%), compared to the patients treated with placebo (3%). One patient receiving Savella 100 mg/day (0.2%) had an increase in ALT greater than 5 times the upper limit of normal but did not exceed 10 times the upper limit of normal. Increases in AST were more frequently observed in the patients treated with Savella 100 mg/day (3%) and Savella 200 mg/day (5%) compared to the patients treated with placebo (2%).
The increases of bilirubin observed in the fibromyalgia clinical trials were not clinically significant. No case met the criteria of elevated ALT > 3x ULN and associated with an increase in bilirubin ≥ 2x ULN.
There have been cases of increased liver enzymes and reports of severe liver injury, including fulminant hepatitis with milnacipran from foreign postmarketing experience. In the cases of severe liver injury there were significant underlying clinical conditions and/or the use of multiple concomitant medications. Because of underreporting, it is impossible to provide an accurate estimate of the true incidence of these reactions.
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from
http://www.rxlist.com/savella-drug.htm
As time passes, we should know more about it.
Cymbalta's damage is worse IMO so far.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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