Originally Posted by mrsD

SNRIs include: They are mixed and have some SSRI actions.
Effexor
Cymbalta
Savella -- this one is higher in SNRI functions

Cymbalta can cause liver damage. All of them can raise blood pressure.

There is a pain loop in the brain that involves certain tracts in the brainstem and trigeminal nerve system. Serotonin and norepi are involved in this loop. It is thought that increasing serotonin and norepi for some patients increases inhibitory actions and prevents the pain from "taking hold" or becoming a fixed response.

Because Savella is new in US not much is known here about discontinuance problems. The other two have significant discontinuance issues. Savella has been in Europe and Japan for quite a while now. It is being recommended for fibro patients.

Can't say how you will react. You'll just have to try it.

I personally think Cymbalta is too problematic.