glad you found this site! i was diagns. in feb and working through mestinon ,may change to imuran. i have been 100% diabled since 2001 from something else that will never go away. i wonder if you have a good reaction to mestinon-do you feel worse when it wears off? if you were just trudging along without meds would you not feel worse since you never felt better>>> how do you know if it's mg or mestinon reaction or fatigue or just "lazy"[i mean not used to doing the things you can do on meds] that is one of my things to figure out but how??????