Ceregene CEO in his interview with mJFF said pretty much the same. They found their gene product at the site of injection but not getting transported thru axons. Now it looks like there is a defect in the transport of dopamine and so probably there is accumulation of dopamine in neurons. Another recent paper says excess dopamine is toxic to neurons........The more we know about PD, the harder it gets to swallow all those pills that increase dopamine/its effects.
girija
Quote:
Originally Posted by imark3000
is the following:
" Dr. Robert Burke, the Alfred and Minnie Bressler Professor of Neurology (in Pathology) at Columbia University Medical Center, and his colleague Ms. Tinmarla Francis Oo, senior staff associate at Columbia University Medical Center, further discovered that the dopamine deficit came from disintegration, not of the dopamine neurons themselves, but of their axons, the long, filament-like structures responsible for transmitting dopamine to distant targets in the brain. Their insights, says Dr. Li, are helping us understand the disease at a deeper level -- something that will lead us to better treatments and possibly even a cure for Parkinson's disease.
"
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