Hi. I am sorry about your wife and it is very nice of you to be so helpful to her by looking for answers. I am sorry if I repeat the other response I am little off today. I do know how hard it is when new pain develops or something happens like with your wife to not fear it turning into rsd. I will say for me yes my rsd has spread but I also had a very severe back issue and pelvic that was here for a long time but was not rsd. Does your wife have a good pain doctor who deals with rsd? I am not sure of that block but possibly meds or a treatment can help her overall with all these symptoms. As for waking up do you think it is cause she has rested it all night? See to me I could never tolerate cold water it would send me into a flare up for a days I need very warm but everyone is different. I am not sure about the water part either but I do feel she needs to follow up with someone cause if it is a spread then quick treatment is so much better but also if it is not then you want to check that as well.