Xmas ~ I have been on 100 mg of Imuran since December. The only side affect that I am fully aware of is hair loss. My doctor did tell me that it could take 6-9 months to really kick in. So I guess that I am just now entering that stage. I am being tapered off of pred. and I take mestinon 60 mg 4-5 times a day. Take care ~ Melanie