The biggest single change I made, almost 20 years ago (had rsd since 83), was to be put on "Methadone".
A "Life Changer".
It doesn't fade in efficacy. (I don't have to keep increasing it over the years). I've been started
@60 mg, been down to 10-15, up to 100 (2nd accident), now I'm back to 50-60/day.

Funny story, my first wife said "I'm not going to be married to a "drug addict". I replied, I'm not going to live my life in pain. She split, and three months later, called, screaming at me why I'm not begging her to come home?

Huh?
You filed for divorce! I decided to not live in pain, nor with one!

Oh well.
Life does go on!

Pete
Asb