Quote:
Originally Posted by fmichael
Mrs. D -
But the papers on morphine glial cells do not explain the vasodilation/edema of CRPS, whereas high levels of CGRP might, don't you think?
From my perspective, any theory of CRPS, not simply one's garden-variety back pain, that can't address vasodialation, can only explain how too high an opioid comsumption can only make our pain worse. And beyond that, may not worth the paper it's printed on, at least as to CRPS per se. Unless it can. Please discuss.
Mike
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You are right up to a point.
What I see, is that the glia which holds the spinal cord and
brain together, is an active promoter of inflammatory cytokines. The RSD response is complex. Certainly the vaso effects are obvious. But then there is the PAIN part...some of that IS mediated in the brain centrally. I have been reading here some members who have had tolerance to opiates and also new pain/burning--the Opana posts by Dew. These responses are in addition to the regional damage, IMO. So I put this up because....because use of opiates for all chronic pain is on the table now, and may be very altered in the future. Based on the attitude of the specialist neurologists I heard discuss many chronic pain states, opiates are not going to be popular in the near future. That is unless Big Pharma finds a way to block this glial response, soon.
It just might be that the anti-inflammatory diet, helps with these issues as well as those in the periphery. I know myself that certain foods trigger my PN pain and burning significantly.
It stands to reason that others with chronic pain are also in a similar situation.
(I don't use opiates, BTW)
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Weezie looking at petunias 8.25.2017
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