I have RLS.
Actually that article is quite interesting from my point of view. Apart from the fact that it references some of Roger Kurlan's work, I find it interesting for a few other reasons. Kurlan is a member of the Tourette Syndrome Association Medical Advisory Board. The acticle referenced speaks about 2 patients who found that they developed tolerance or declining response to the medications and suggestions about improving that. (as an aside, I see that Kurlan has also written a paper regarding "dopamine phobia" in patients who have Parkinson's Disease.)

I've personally never taken any pharmaceutical medications for my RLS although I can assure you that I've been tempted at times when I've wanted to jump of a cliff to stop the edginess and restlessness, and I mean that quite seriouslly. Because it sounds like a fairly painless syndrome because of the name, it's actually something quite dreadful and I have much empathy for anyone who has this problem.

I have a few minor motor tics. One major observation that I've found over the years since my childhood has been that my RLS is much worse at the times when I have no tics, and visa versa. Obviously related to dopamine dysregulation, but I'd hate to think what would happen if I started using a dopamine agonist for RLS or even a dopamine antagonist for the tics, although that wouldn't happen.

I have also noticed in the past few years though, that some doctors have treated patients who have debilitating tics with some low dose dopamine agonists although it isn't that common a practice.