Daniella;

Of those meds you mention, I take the zanaflex @ bedtime. Works well. It can easily be titrated up, for daytime use, but slowly.

However, I advise you to be VERY careful of Seroquel. It can be an absolute Monster!
It's an "Atypical" anti psychotic. That is for Bipolar disorder, and something i can't spell. (Psychosis)? If you don't have either of those, stay away from this drug. (Imho)~!

The side effects are terrible, and I've witnessed them with a wonderful friend.
Acting out in the middle of the night, with no memory of it. and just generally causing havoc, that with this disease, nobody understands to begin with, do we need to add a drug like that on top of it?

Please, educate yourself, on Seroquel! Google it, and read as much as you can, especially all the lawsuits that are flying because of "off label" prescribing.
It's a very dangerous drug, as are all the "Atypicals"!

Peace,

Pete
Asb