Also have PN and IBS. Until recently, I was on Limbitrol DS (Amitriptyline/CDP) for 6 years. Amitrip is anti-cholinergic so that helps the IBS with no additional meds required. A recent second opinion by a neuroligist resulted in a recommendation for Lyrica - it's a newer drug for diabetic neuropathic pain and is also used for pain from ideopathic neuropathy. Neither drug appeals to me so a Web search turned up Ranirestat, a Japanese drug now in clinical trials in the US. Based on Phase II trials at the University of Toronto, nerve function improved. Unfortunately, it's not available yet and patients eligible for the trials must be diabetic. I've been told that there's no cure for my particular type of nerve damage except stem cell research. I can't even get the neurologists to agree on the effect of Amitrip on nerve function: does it simply mask pain or actually assists in nerve healing.