So far, all I take is Mestinon - but I am newly diagnosed. My follow up appointment is next month, so perhaps there will be discussion on prednisone. They were quick to point out that Mestinon does not cure - it just controls. The dosage and the effectiveness is different between people and even for the same person on different days!

My impression was that prednisone is an attempt to 're-set' the immune system in the hopes of remission, but I don't know that for a fact. (Bet more experienced folks can tell us!)